Services
Upstream
Cultiply is a comprehensive platform for the development (CRO service) and production (CMO service) of a wide variety of microorganisms, proteins, enzymes and other biological components.
Medium optimisation
In our company, we develop and optimize the culture medium using methodologies based on Design of Experiments (DoE). This phase is crucial to guarantee a profitable and efficient bioprocess in terms of the cost and quality of the final product. The aim is to use suitable ingredients for the bioprocess in question, not only from a technical point of view but also from an economic one.
The optimization of the culture medium is an important element in the development of a process for the production of compounds with high-added value. To do this, we use methodologies based on DoE that allow us to identify the most important variables that affect the fermentation process and adjust them to optimize production.
First of all, we evaluate the ingredients that make up the culture medium and select those that are suitable for the bioprocess in question. Next, we use the DoE methodology to optimize the concentrations of each of the ingredients, as well as the cultivation conditions, such as temperature, pH, fermentation time, and agitation, among others.
The DoE methodology allows us to generate a mathematical model that relates the process variables to the desired response, in this case, the production of the compound of interest. Using this model, we can optimize the culture medium and culture conditions to maximize compound production and minimize costs.
In summary, in our company, we develop and optimize the culture medium using methodologies based on the design of experiments (DoE). This allows us to identify the most important variables that affect the fermentation process and adjust them to optimize the production of the compound of interest. We use suitable ingredients from both a technical and economic point of view, which allows us to offer a bioprocess with a good cost-efficiency ratio.
Bioprocess optimisation
Cultiply focus on optimizing the bioprocess to achieve maximum efficiency in the production of our products. For this, we have a highly trained team with more than 20 years of experience in the field of industrial microbiology.
One of our main objectives is to optimize the most important process variables, such as temperature, pH, agitation, and gas flow, which allows us to obtain a high-performance, scalable, and safe production system.
To achieve this, we use laboratory-scale stirred tank bioreactors in three modes of operation: batch, fed-batch, and continuous, depending on the needs of the project. This allows us to simulate full-scale production conditions and find the best combination of variables to maximize production.
In addition, we use advanced monitoring and control techniques to ensure that the process runs optimally at all times, allowing us to detect any problem or deviation in real-time and take corrective actions immediately.
All this is done to ensure high-quality production and an adequate cost-efficiency ratio, which allows us to offer our customers high-quality products at competitive prices.
Scale-up
At Cultiply, we specialize in taking biotechnological processes from the laboratory to large-scale production. For this, we have a modern production plant equipped with bioreactors of different scales. Once the process has been optimized on a laboratory scale, we scale it up to a bigger volume to check its robustness and reproducibility at an industrial level.
Our bioreactors are designed to offer the best culture conditions, allowing optimal growth and production of the desired microorganisms and compounds. Thanks to our experience and knowledge in the sector, we can carry out scaling efficiently and safely, ensuring the quality of the final product.
In addition, at Cultiply we understand that some projects may require even greater production capacities, which is why we have a wide network of partners with production capacities above 1,500 m3. This way we can guarantee that your project reaches the desired scale and that it is produced efficiently and profitably.
