Microbial bioreactor design and manufacturing solutions

At Cultiply, we design and build high-performance microbial bioreactors tailored to your biological system, production goals and scale. Whether you’re working with E. coli, yeasts or other microorganisms, our solutions deliver the precision and control needed to maximise productivity. Think of our bioreactors as intelligent vessels—engineered to bring out the best in your microbial cultures. From research to GMP manufacturing, we offer expert-driven design, fast turnaround, and long-term support. Let’s co-create the next generation of microbial fermentation, with science and scalability in harmony.

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Design and purchase of custom microbial bioreactors

Every fermentation process has its own rhythm—so we don’t offer off-the-shelf solutions. At Cultiply, we work with your team to design stainless-steel bioreactors tailored to your process requirements: from oxygen transfer and agitation to pH control, cleanability, and CIP/SIP. Need integrated sensors (pH, DO, off-gas) or automation-ready controls and data logging? We’ll build it to spec. Once the design is finalised, we manufacture, deliver, and commission your bioreactor so it’s ready to run. Tailored engineering. Seamless commissioning. Reliable results. That’s the Cultiply approach.

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Key features of our microbial bioreactor systems

Cultiply bioreactors are designed for performance, flexibility and control. Key features include high-efficiency aeration, scalable agitation systems, automated control of pH and DO, and customisable vessel geometries. We supply robust stainless-steel systems with options for clean-in-place (CIP), steam-in-place (SIP), and full GMP compliance. Need real-time data? We integrate advanced sensors and SCADA connectivity for effortless monitoring. Whether you’re optimising expression in P. pastoris or scaling up for industrial production, our systems adapt to your goals—down to the last detail.

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Applications of microbial bioreactors across industries

Microbial bioreactors power a wide range of industries—from biopharma to agrotech. They’re used to cultivate E. coli for recombinant protein production, Pichia pastoris for enzymes, and even microalgae for biofuels and nutraceuticals. In food tech, they enable the precision fermentation of flavours and alternative proteins. Whether you’re scaling up vaccines, producing bioplastics or fermenting probiotics, microbial systems offer control, efficiency and sustainability. Each process is unique—and Cultiply designs bioreactors that speak your organism’s language and meet your industry’s demands.

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Why choose Cultiply for your microbial bioreactor project

At Cultiply, we don’t just supply bioreactors—we engineer complete microbial fermentation ecosystems. Our multidisciplinary team works closely with you to design systems optimised for your specific strain, productivity targets and regulatory needs. From oxygen transfer and agitation control to GMP readiness and scale-up modelling, we handle it all in-house. The result? A bioreactor that works with your biology—not against it. If you need a partner who speaks both microbial science and industrial reliability, Cultiply is ready to collaborate.

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Frequently asked questions about microbial bioreactor design

Cultiply bioreactors are designed to support a wide range of microorganisms, including E. coli, Pichia pastoris, Bacillus, lactic acid bacteria, microalgae and more. Whether your process requires aerobic or anaerobic conditions, high-density cultivation, or specific feeding profiles, our systems are engineered for flexibility. If your strain has particular oxygen or shear sensitivity, we’ll adapt the design accordingly—because the bioreactor should fit your biology, not the other way around.

We design systems from benchtop scale (0.5–10 L) for R&D and process development, up to pilot and production volumes exceeding 10,000 L. Each unit is built with scalability in mind—preserving your key parameters like oxygen transfer rate (OTR), mixing profiles and feeding strategies. Whether you’re scaling up or scaling down, we ensure data consistency and seamless process transfer between volumes.

 Yes—our systems are optimised for high cell density (HCD) fermentations, reaching OD600 values well above 150 depending on strain and process. We incorporate efficient oxygenation strategies, high-performance agitation, and tailored feeding control. Combined with robust pH and DO management, this ensures cell viability and productivity, even in intensive microbial processes such as recombinant protein or plasmid DNA production.

Our bioreactors come with precise control of pH, dissolved oxygen (DO), temperature, agitation, aeration and feeding profiles. We also offer advanced sensor integration (optical, capacitance, redox, etc.) and full SCADA/PLC compatibility. Whether you need simple control panels or fully automated GMP-compliant systems, our bioreactors are built to match your operational model—ensuring consistency and traceability from batch to batch.

Customisation is at the heart of our service. From vessel geometry and sparger design to impeller type and automation level, we tailor each system to your microorganism and production goals. Need an anaerobic chamber, light exposure for microalgae, or specific gas mixing? We can build that. Our team of engineers and microbiologists works with you to create a bioreactor that’s not just functional—but optimised.

We design with scale-up in mind from day one. Our approach ensures that fluid dynamics, oxygen transfer rates and feeding strategies remain consistent across volumes. We support you through modelling, data transfer, validation and equipment commissioning—minimising risk as you grow. Think of us as your process partner, not just a supplier. Your success at scale is our shared goal.

We provide full technical support before, during and after delivery. Our services include installation assistance, operator training, preventive maintenance, remote troubleshooting, and access to process engineering advice. You’ll have a dedicated point of contact and ongoing collaboration opportunities as your process evolves. At Cultiply, we believe true support begins after delivery—and continues through every fermentation run.

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    “Cultiply S.L. ha recibido una ayuda de la Unión Europea con cargo al Programa Operativo FEDER de Andalucía 2014-2020, financiada como parte de la respuesta de la Unión a la pandemia de COVID-19 (REACT-UE), para compensar el sobrecoste energético de gas natural y/o electricidad a pymes y autónomos especialmente afectados por el incremento de los precios del gas natural y la electricidad provocados por el impacto de la guerra de agresión de Rusia contra Ucrania.”

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